Stem Cell Treatment in Malaysia

Stem Cell Treatment for Stroke

Research Protocol registered with Stem Cell Registry of the Ministry of Health, Malaysia:

Presented at the 3rd International Association of Neurorestoratology Annual Congress (IANRAC III), Beijing 23-25 April 2010:
Foo-Chiang Lee (Malaysia): Multicentre phase II study assessing the safety and efficacy of intracerebral autologous mesenchymal stem cells in chronic stroke patients
http://www.ianr.org.cn/English/new.asp?id=1226

Forthcoming presentation at 8th Asian Congress of Neurological Surgeons, Kuala Lumpur, 20-21 November 2010:

Dr. Chee-Pin CHEE, Foo-Chiang LEE, Dr. Moon-Keen LEE, Sze-Piaw Chin, Zaliha Omar.  Autologous bone marrow stem cell transplantation for stroke patients: an initial report.


ABSTRACT OF PAPER presented at IANRAC III Beijing

MULTICENTRE PHASE II STUDY ASSESSING THE SAFETY AND EFFICACY OF INTRACEREBRAL AUTOLOGOUS MESENCHYMAL STEM CELLS IN CHRONIC STROKE PATIENTS.

Dr. Foo-Chiang LEE 1, Dr. Chee-Pin CHEE 2, Dr. Moon-Keen LEE3, Assoc Prof Sze-Piaw Chin4 and Dr. Zaliha Omar5

Consultant Neurosurgeon1, 2, Neurologist3, KL Advanced Neuroscience Associates, Rehabilitation Physician5, Sunway Medical Center, Clinical Research Advisor4, Cytopeutics Pte Ltd, Malaysia.

Stroke is a leading cause of mortality and morbidity worldwide. In Malaysia it accounts for 10,000 patients and 9% of all hospital deaths per year. Initial treatments are aimed at reducing acute brain damage and cerebral protection. This study is to evaluate new modalities of stroke treatments 6 months after the initial phase and natural recovery. Stem cells therapy has offered a novel neurorestorative option having been proven in in-vitro and some clinical settings. Bone Marrow-derived mesenchymal stem cells (BM-MSC) have anti-inflammatory effect in modulating acute brain injury and promote angiogenesis in ischemic rat brains and neurogenesis in the chronic phase. However efficient delivery to the area of infarct remains a challenge. In this clinical study, body weight based dose of BM-MSC is administered via a minimally invasive stereotactic intracerebral implantation to selected MRI based target sites. Size of infarcted areas on serial MRI Brain, overall symptoms, functions and quality of life will be determined. NIHSS, Bartel Index and Modified Rankin Scale assessment will be done up to 2 years.

  1. 9 April, 2014 at 11:11 PM | #1

    hello dr ,
    my brother is 30 years old and he has a problem of cerebral palsy . as he is quite fine ,i mean his physical capabilities are normal amongst other patient of CP .there is slight problem in walking ,tallking , sometimes he faced dificulty in legs .i want to know is there any cure with stem cells . which can be obtain through bone marrow.. plz tell me can it be cured..

    • 16 April, 2014 at 6:17 PM | #2

      Dear Deepti

      It is good that your brother is at a high functioning level. The best currently available treatment for cases like him consists of physio and rehab. We reproduce here our reply to a previous enquiry:

      “Stem cell treatment is not yet approved for treatment of cerebral palsy. This paper http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057381/ summarises the state of our knowledge, including lack of proven benefit and risks of treatment. The conclusion of the paper is below:
      Current clinical trials in the use of stem cells for cerebral palsy are on-going and incomplete. While there are a number of different cell types that are potential candidates as treatments, none have been shown to be effective in chronic animal models. Furthermore, available animal models do not adequately mimic cerebral palsy. Risks of the treatment are reported. More work on understanding the underlying beneficial biology of stem cells and the development and validation of more relevant animal models is required.
      Research centres are listed in the paper.”

      Best wishes, Webmaster

  2. yuwanisan
    5 March, 2014 at 11:20 PM | #3

    HI Doctor,
    My mum having neuro problem can we solve with stem cell
    where should i consult ..pls give me a contact

    thanks
    uva

    • 10 March, 2014 at 9:32 AM | #4

      Dear Uva

      Stem cells are under research study for a few neuro conditions. The results of these patient trials are being awaited. Until then, stem cells are not yet approved for routine clinical treatment.

      Best wishes, Webmaster

  3. Jeff
    16 February, 2014 at 10:02 PM | #7

    Hello Dr,

    Is it possible to try out MSC treatment here in Malaysia for chronic kidney disease? Has there been any development elsewhere on MSC to treat CKD? Thanks.

    • 18 February, 2014 at 8:21 AM | #8

      Dear Jeff,

      Our panel are specialists in the field of neurosciences. Do please consult a Nephrologist for your query.

      Best wishes, Webmaster

  4. rach
    11 February, 2014 at 10:52 PM | #9

    Dear Doctors,

    My father has suffered from a cardiac arrest on the 6th of Dec 13 (in an operating theatre). He was resuscitated and was sent into the ICU. When he regained consciousness on the same day, he was able to open his eyes but he was having hiccups continuously hence he was given sedation to prevent him from further brain traumas. The sedation was taken off on the 9th of Dec 13. At that time he was only able to open his eyes (floating) and there was no movement at all. It’s been 2 months since then and up till now, he has been showing very soft signs of improvement. Ex: Movement in the upper and lower limbs, eyes seem to be more focused although we aren’t sure if his vision is still intact. What i’d like to ask is for a patient to not go into a coma post cardiac arrest, and to be showing improvements as such, is there a possibility that stem cell treatment might be able to aid in the recovery? And is there any risk in the procedure?

    • 20 February, 2014 at 11:06 PM | #10

      Dear Rachel,
      Stem cells are now under intensive research for brain injury and other conditions, and beneficial results are being awaited. As such, stem cell therapy is not yet approved for routine clinical treatment.

      Webmaster.

  5. eunice quist
    3 February, 2014 at 2:27 PM | #11

    Dear Dr Lee,
    My husband suffered a stroke and I want to find out if the stem cell therapy can help him recover fully.he is paralysed on the left side.
    Thanks Eunice from Ghana

    • 18 February, 2014 at 7:42 AM | #12

      Dear Eunice,

      Stem cells are now under intensive research, and beneficial results are being awaited. As such, stem cell therapy is not yet approved for routine clinical treatment.

      Best wishes,
      Webmaster
      On behalf of Dr Lee

  6. marvelous
    24 January, 2014 at 9:58 PM | #13

    my husband has been diagnosed with rheumathoid artrithis and now suffering from severe joint pain and inflammation, andrecently a bit of deformation on his joints. can stem cell therapy help?

    • 27 January, 2014 at 4:45 PM | #14

      Dear Marvelous

      Thank you for your enquiry. For info, we are a team of specialists in the clinical neurosciences, and are not able to comment on treatment for joint conditions.

      Best regards, Webmaster

  7. Hafiz
    20 January, 2014 at 12:58 PM | #15

    Dear Dr Lee,

    My father had parkinsons since 20 years ago and we constantly monitor his health with medication and visits to the neuro. Currently he’s on Madopar HBS 125mg, Comtan, Jumex and just recently told by the neuro to stop artane(apo-trhex). I read a lot about stemcell treatment for parkinsons patient. There are mix views on the procedure itself. Do we have it here in Malaysia and do they get good result on it ? Do you have it at your clinic/hospital ? Im not expecting a full cure on the desease but a slight improvement will surely improve the life quality of my father.. Would be glad to fix an appoitment with you.

    TQ Sir..

    • 21 January, 2014 at 10:19 AM | #16

      Dear Encik Hafiz

      Stem cell treatment for Parkinson’s disease has been under study for decades. The initial studies used foetal stem cells obtained from aborted foetuses. The results were disappointing and so direction has been turned to other forms of treatment. In addition, there are massive ethical concerns with the use of such human sources of cells. As for other types of stem cells, there are no results to indicate benefits for PD.

      Some encouraging results have been obtained in PD centres from research trials of gene therapy (sometimes mis-interpreted as stem cell therapy), but this is still not ready to be offered for routine application.

      For info, there have been significant advances in medications available for PD. Perhaps while waiting for the above research to bear fruit, your father could consider adjustments to his drug therapy.

      Best wishes,

      Dr Lee Moon Keen
      Consultant Neurologist

  8. Joyce Chuah
    18 January, 2014 at 1:15 AM | #17

    Dear Dr Lee

    My mum is 84 years old and has acute sciatica. She has pains in her thighs and buttocks. We have tried almost everything including epidural injections. The only thing we have not done is surgery, Can stem cell therapy help her? She is in good health condition but suffers severe pain daily.

    • 21 January, 2014 at 10:45 AM | #18

      Dear Ms Chuah

      Thank you for you enquiry. To date there are no reports of stem cell therapy for acute sciatica.

      Best regards.

      Webmaster
      on behalf of Dr Lee Foo Chiang

  9. Jane
    2 January, 2014 at 6:56 PM | #19

    Dear Dr.Lee

    Can this stem cell treatment cure autism child age 3?

    • 10 January, 2014 at 9:25 AM | #20

      Dear Jane

      Thank you for contacting us. For information, we reproduce here our response to a previous enquiry:

      “Stem cells are being studied in the lab for better understanding of autism. This link explains the study of hiPSC cells, which are derived from the skin of autistic people: http://autism-center.ucsd.edu/what-causes-autism/Pages/stem-cell.aspx.”

      We have previously stated that to date there are no reports of stem cell therapy being beneficial for patients with autism spectrum disorder.

  10. Nidhi
    3 December, 2013 at 1:23 PM | #21

    Hey is there any treatment through stem cell if a patients urine and stool sensation has been lost. The nerve has been damaged completly. Please advice me if there is any treatment it would be really helpfull.

  11. Gary Teh
    10 November, 2013 at 3:34 PM | #23

    Dear Dr Lee,

    Is it possible to treat pulmonary fibrosis with stemcell therapy? My wife was diagnosed recently and I’m hoping that this therapy might help her. Thanks

    • 11 November, 2013 at 4:22 PM | #24

      Dear Mr Teh

      Thank you for your enquiry. For information, we are specialists in the clinical neurosciences and won’t be able to comment on treatment of lung conditions.

      Best regards.

  12. Wun miew Khin
    20 October, 2013 at 11:06 AM | #25

    Dear Dr Lee
    My husband had a tongue cancer and undergone radio therapy at Beacon hospital in Nov 2012. He is now suffering from all the side effects like woody neck and his C5 and C6 nerves for his left hand is damaged hence he is not able to lift up this hand anymore, his right hand is also feeling numb and weak now.
    Will stem cell therapy help for his case?
    Thank you and all the best.
    MK

    • 22 October, 2013 at 10:43 AM | #26

      Deawr Madam Wun

      There are as yet no studies of stem cell treatment for post-radiation injury. Perhaps you could discuss with the Oncologist whether any other treatment might be of benefit for such cellular damage.

      Best wishes.

      Dr Lee Moon Keen
      Consultant Neurologist

  13. Nik Zarina Nik Mahmood
    19 October, 2013 at 10:16 PM | #27

    Dear Dr Lee,
    my husband collapsed on 19 Sept 2013 at hospital due to acute pulmonary edema secondary to fluid overload and acute coronary disease. dr resustated him 10-15 mins before he returned to sinus rythm. EEG done and suggestive of severe diffuse cortical injury . At the moment he remained comatose and only respond to deep pain , occasionally moves his limb. he is also suffered from end stage renal failure and is on hemodialysis since April 2013.
    kindly advise us whether stem cell treatment can improve his condition eventhough we don’t expect full recovery

    thank you
    Zarina

    • 22 October, 2013 at 11:06 AM | #28

      Dear Puan Nik Zarina

      To date, there are no published results of benefit from stem cell treatment for brain injury post-collapse. Stem cell treatment will be considered for approval by the authorities once this evidence is available in the future.

      Best regards,

      Dr Lee Moon Keen
      Consultant Neurologist

  14. alex teo
    16 October, 2013 at 9:26 AM | #29

    hi, Dr. lee i have two children with auditory neuropathy, will stemcell therapy help them, or in any terms of recovery, i get to know recently in UK there is reports of improvement, is there any research on this in malaysia.

    • 17 October, 2013 at 10:49 AM | #30

      Dear Alex

      For information, we don’t manage auditory conditions. You are therefore advised to consult your children’s ENT specialists about this matter.

      Best wishes.

  15. Suanny Lee
    6 October, 2013 at 11:28 AM | #31

    Dear Dr Lee,

    My husband is under botox treatment for cervical dystonia and aslo taking arthane tablets. can he also take live cell therapy by way of capsules. will there be any adverse effects?

    Your opinion is of great value to us. Many thanks, Dr. Lee.

    • 9 October, 2013 at 8:01 PM | #32

      Dear Suanny

      There should be no problem of interaction between botox and other medications except on the days before and after the injection procedure.

      As for Artane, please check with your doctor whenever new medication is to be given.

      We have no information concerning the potential medical effects – beneficial or adverse – of “live cell therapy”.

      Best wishes.

  16. Jessie
    3 October, 2013 at 9:36 AM | #33

    Hi Dr. Lee,

    My daughter now is 16 months old, Dr suspected her is CHARGE syndrome child and now her retarded in central nervous system. Does the stem cell transplant can improve the central nervous system? I have stored her cord blood as well. Thanks.

  17. Jaclyn chin
    1 October, 2013 at 12:51 PM | #34

    Dear dr,
    I hv a friend who Juz gone blind for 4 mths due to diabetic. Is there any hospital in Malaysia that can do stem cell for his eyes? can he get back some vision? Thanks

    • 2 October, 2013 at 4:51 PM | #35

      Dear Jaclyn

      We don’t treatment eye conditions. Your friend needs to discuss with his eye specialist about options for treatment, including stem cells.

      Best wishes.

  18. Tiffany
    27 September, 2013 at 11:23 AM | #36

    Dear Dr,

    My brother in law has just recently had an accident where he sustained quite severe brain injury. We do not know the extent of the damage as of now yet as he is in the the ICU. However, we were told to be prepared that he might not be able to function as normally as before even if he wakes up.
    I’ve read somewhere that stem cells are being researched to be used for brain injuries and the results have been positive so far. Since I am at my 36 weeks of pregnancy, I am considering storing my baby’s cord blood to see if it can be used for my brother in law’s future use. At 36 weeks i might be due at any time and so i need to make this decision fast.
    My question is, what are the chances of the cord blood matching my brother in law’s as so far I’ve read that mainly siblings could benefit from it. My brother in law and my husband are twins and as such i remain hopeful.

    Your opinion and advice is appreciated.

    • 28 September, 2013 at 11:07 AM | #37

      Dear Miss Tiffany
      Stem cell treatment for strokes and other central nervous system condition is still considered a clinical experimental treatment and has been approved on a case by case basis by some hospitals.
      Even if the cord blood does not match the recipient, we can still harvest patients own bone marrow from the iliac crest and culture (autologous).
      3-4 Injections is given in stages over 1,3,6 months intervals.
      Improvement have been shown on cases but this has not been proven on large series reports.
      Thank you.
      Dr. Lee Foo Chiang
      Consultant Neurosurgeon.
      Sunway Medical Centre

  19. Peggy
    24 September, 2013 at 6:13 PM | #38

    Dear Sir,

    Is Bell Parlsy is stroke??. I have bell parlsy 4mths ago,it stem cell can cure?

    • 26 September, 2013 at 8:06 AM | #39

      Dear Peggy

      Bell’s palsy is not due to stroke. It is a temporary paralysis of the facial nerve, most commonly due to a preceding virus infection. Treatment consists of anti-viral and anti-inflammatory medications, and perhaps supplementary physiotherapy. Stem cells are not indicated for Bell’s palsy.

      Best wishes.

  20. Mr Chow
    24 September, 2013 at 6:04 PM | #40

    Dear Doctor, I had stroke 2yrs ago. I had blood clot and had operation at my right side. now my leg and hand unable move well. My left hand unable to grab. it stem cell therapy can help? Where can I find in Malaysia? I am 42 yrs old.

    • 28 September, 2013 at 11:23 AM | #41

      Dear Mr. Chow,
      Stem cell treatment is classified as clinical experimental treatment in Malaysia. Approval has been given by some hospitals but is on a case by case basis.
      You can contact us to discuss the procedure.
      Thank you.
      Dr. Lee Foo Chiang
      Consultant Neurosurgeon
      Sunway Medical Centre.

  21. Hai
    5 July, 2013 at 12:43 AM | #42

    Dear Dr Lee,I’m 29 and has knee problem ,had my arthroscopy at 28 to my right knee and that didnt help,now both my knees are hurting.Is there any successful stem cell treatment for the knees?And what are the cost?Im from Sydney.Thank you
    Hai Vuong

    • 5 July, 2013 at 9:38 AM | #43

      Dear M. Hai Vuong

      Thank you for your enquiry. For information, we are specialists in the clinical neurosciences. For joint treatments, you will need to consult an orthopaedic specialist for advice.

      All the best,

      Webmaster.

  22. Leonard Chang Foh Soon
    14 June, 2013 at 6:04 PM | #44

    Dear Dr. Lee,
    I am 63+ years old and am a pensioner. I have just been diagnosed with suffering from MND and will be on Riluzole. Is there any successful stem cell ( I mean just to stop the degeneration of the motor neuron) treatment for MND? What is your advice for people suffering from MND? Is there an MND Association in Malaysia where patients can get useful informations on managing MND? Thank you
    Leonard

    • 15 June, 2013 at 4:45 PM | #45

      Dear Mr Chang,

      At present the most established treatment for MND is still Riluzole.

      We have previously stated the following info on stem cells:
      There have been isolated case reports of stem cells for motor neuron disease. For the first in-human trial of embryonic stem cell treatment which is underway in the US, please refer to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154698/pdf/nihms303395.pdf

      The general advice is to stay active by regular exercise and physiotherapy, supported by good nutritional status.

      There is no MND association in Malaysia. You can follow the site of The International Alliance of ALS/MND Associations, which has chapters in Asia. The ALS Therapy Development Institute is currently involved in the study of new drugs including
      TDI-132 (Gilenya) and TDI-846 (aCD40L) http://www.alsmndalliance.org/directory/united-states-of-america.html.

  23. Jordan
    10 June, 2013 at 11:24 PM | #46

    Dear Dr Lee,
    What is your opinion on stem cell therapy for autism?

  24. rokiah
    22 May, 2013 at 3:25 PM | #48

    hi dr,

    Saya mempunyai masalah limb girdle mascular dystrophy..boleh ke saya megambil rawatan stem cell

  25. ronald
    18 May, 2013 at 1:51 PM | #50

    dear dr lee,

    my father, who is 71 yrs old, had a fall last oct and this had injured his spinal cord c2, c3 and c4. initiate stage was almost like bedridden. he is now better as he can walk for short distance and stand for a few minutes with the support of a cane. however, this injury still affect his bowel and bladder ability and he is still having numbness in both his hands. he is still using a catheral to urine while the sensitivity of bowel is still not a normal level. i would like to know if stem cell treatment able to improve his condition and which hospital in malaysia has such facility.

  26. affin
    16 May, 2013 at 12:40 PM | #52

    Dear Dr Lee
    Saya sudah lumpuh 8 tahun karena cidera spinalcord level c4, c5 dan c6, apakah saya dapat menjalani stemcell treatment di malaysia? Thank you

  27. Alan Ng
    20 April, 2013 at 12:13 AM | #54

    Dear Dr. Lee

    My brother got heart attack after playing badminton on 25th March, his brain got hypoxia and neurologist in Ipoh hospital suspected there was mild to serious brain damage.

    Today is his 25th day in hospital, he can sit but can’t really stand and walk. He can say some simple words and can understand what we say “sometimes”, he can also recognize his families and friends “sometimes”. “Sometimes” means he can remember sometimes, but cannot sometimes.

    Doctor in Ipoh said the brain damage is not reversible; and my Taiwanese neurosurgeon friend said that he had 3 months of recovery, the brain recovery will stop or progress slowly after 3 months; if that’s true, my brother still has about 2 months of recovery or rehabilitation.

    Kindly tell me if the stem cell treatment can cure the damaged cells and repair the brain, is it possible for my brother to become a normal healthy person again?

    Thank you very much.

    • 20 April, 2013 at 12:26 PM | #55

      Dear Mr Ng,

      It is most unfortunate your brother developed hypoxic brain damage after heart attack. Stem cell therapy for brain damage, whether sustained at birth (cerebral palsy) or in adult life, is under active study in various centres worldwide. However, there are as yet no proven benefits.

      In the mean time, the patient’s best chances reside in intensive rehabilitation. Your doctor would be able to provide a realistic prognosis as to whether he could become normal again or not. Please note that the time frames given by the doctor can only serve as guidance, not fixed timelines.

      Here is a link to the current status of cell therapy for birth injury http://www.ncbi.nlm.nih.gov/pubmed/22522476

      Best wishes.

      Dr Lee Moon Keen
      Consultant Neurologist

      • Alan Ng
        20 April, 2013 at 6:12 PM | #56

        Dear Dr. Lee,
        First I’d like to thank you deeply. My brother is 40 years old and is now in Ipoh Hospital.

        I know intensive rehabilitation will help my brother. Could you recommend any hospital or neurologist that can provide the brain rehabilitation to my brother?

        Because the doctor in Ipoh Hospital told us what can be done now was only “wait and see”, I don’t see any treatment nor rehabilitation for his brain is going on.

        Every day the doctor just came twice to visit him, no specific treatment has been seen.

        Your recommendation is very much appreciated, thank you.

        Regards,
        Alan Ng

      • 12 May, 2013 at 5:09 PM | #57

        Dear Alan

        Thank you for your queries. We are sorry to hear of this unfortunate event. Below is the info you needed:

        1. Stem cell treatment for hypoxic brain damage is still undergoing intensive research. It is not yet approved for treatment as positive results have not not yet been demonstrated.

        2. Intensive brain rehabilitation is indeed the only available option at the moment. There is no definite timeline for rehab, as the maximal damage has occurred at the time of oxygen deprivation (i.e. the heart attack). Do be aware that treatment needs a prolonged period over many months or more.

        Could you kindly refer to your email for a personal reply.

        Best regards.

  28. Angeline
    20 March, 2013 at 8:49 PM | #58

    Dear Dr.Lee, my Dad had a stroke 3 years ago, and he did not know at that time that he had a stroke, because he was admitted at a hospital for an accident, and he was treated for the accident and they did not do a scan to see if he had a stroke. A year and a half later, he started to get more stiff and it was then that we discovered that he had a mild stroke much earlier on. Anyways, the trip after has been downhill. He used to be able to drive and walk independently, even after the mild stroke. But now he seems to be falling more when he walks. Kindly advise if the stem cell therapy will be able to help with stroke patients. Thank you.

    • 21 March, 2013 at 9:05 AM | #59

      Dear Ms Angeline, a few studies are now in progress in various countries to assess the effectiveness of stem cell treatment after acute stroke, i.e. in the early stages of the condition, when it is expected that cells may be rescued before they die off. Once in the chronic stage, physiotherapy and medications are the mainstays of present treatment programmes.

      All the best.

  29. Eureka
    20 March, 2013 at 12:50 AM | #60

    Dear doctor,
    I have premature twin babies borned in 27 weeks and currently they are 1+ yrs old.
    We realised that they may have cerebral palsy diagnosis.
    May I know any stem cell therapy for CP in Malaysia?
    If not, which nearest country have this kind of therapy?
    How much is the cost per treatment?
    Thank you very much for your advice.

    • 20 March, 2013 at 9:47 AM | #61

      Dear Eureka, stem cell treatment is not yet approved for treatment of cerebral palsy. This paper http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057381/ summarises the state of our knowledge, including lack of proven benefit and risks of treatment. The conclusion of the paper is below:
      Current clinical trials in the use of stem cells for cerebral palsy are on-going and incomplete. While there are a number of different cell types that are potential candidates as treatments, none have been shown to be effective in chronic animal models. Furthermore, available animal models do not adequately mimic cerebral palsy. Risks of the treatment are reported. More work on understanding the underlying beneficial biology of stem cells and the development and validation of more relevant animal models is required.
      Research centres are listed in the paper.

      Kind regards.

  30. 12 March, 2013 at 2:22 PM | #62

    Hello Dr.,

    Bapa saya mengidap penyakit Motor Neuron Disease (MND)
    Sekarang ini, dia menerima makanan melalui tiub yang disambungkan terus ke perut.
    Dia tidak mampu bercakap, kedua-dua tangan lemah & tidak berfungsi.
    Walaubagaimanapun dia masih mampu berjalan.
    Adakah stem cell boleh merawat penyakit ini?

    Yang benar,
    Nafiyah

    • 14 March, 2013 at 7:32 AM | #63

      Hi Nafiyah

      Setakat ini, rawatan stem cell untuk Motor Neuron Disease (MND) kini pada tahap penyelidikan (research). Pihak pemerintah tidak sedia membenar rawatan ini untuk pesakit MND kerana belum ada bukti yang dipercayai (“evidence-based”). Kini penyelidikan sedang dijalankan di USA dan China dan kita menunggui keputusan pada masa akan datang. Apabila bukti evidence-based dapat diperolehi, dan difahami cara rawatan serta jenis cell yang sesuai, makin rawatan stem cell akan ditawar kepada semua pesakit MND.

      Sekian, terima kasih.

      • 15 March, 2013 at 9:47 AM | #64

        Thank you Doctor.

        Adakah doktor boleh menjangkakan bila penyelidikan ini akan mendapat keputusan? Pada tahap manakah penyelidikan tersebut pada masa ini? Mungkin jawapan doktor sedikit banyak dapat menggembirakan atau memberi semangat kepada pesakit NMD

        Thank you

      • 16 March, 2013 at 6:16 PM | #65

        Hi Nafiyah, penyelidikan “Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis (ALS)” telah didaftar dengan US National Institutes of Health (ClinicalTrials.gov Identifier: NCT01348451). Setakat ini, belum melaporkan hasil apapun.

        Sekian, terima kasih.

  31. Rozz
    8 March, 2013 at 7:50 PM | #66

    Dear Dr Lee,

    I have only got news that my friend has been down with stroke for almost 2 years already. When I visited him he was all but bedridden. He could talk and has good memories. However his left side is still very weak despite going through many physical therapy. He could not lift his left hands and leg.

    It is interesting to note of the availability of this stem cell therapy and is there guarantee that this could heal my friend if he can afford this treatment.

    Thank you

  32. 24 February, 2013 at 7:20 PM | #67

    Hi Dr. Lee, this is Chew and i would like to convey my deepest gratitude and appreciation to you for all help and i’m keeping myself busy physically and have no time to dwell on Uncle James (parkinson). Interesting page to gain more knowledge on stem cell from an expert in this field.

    Warmest regards,
    Chew

    • 25 February, 2013 at 9:44 AM | #68

      Dear Mr Chew, I’m very pleased to note you are keeping well and even more importantly, upbeat. We sincerely hope the numerous on-going research studies worldwide will yield better treatments in the near future for you and every one else. Happy new year.

      Dr M K Lee

  33. 24 February, 2013 at 5:45 PM | #69

    Saya sudah 7 tahun lumpuh akibat kemalangan,dan saya cedera di tulang belakang di level c5-c6 ,di Malaysia ada tak rawatan stem cell ntuk spinal chord injures?

  34. Deborah C.
    11 January, 2013 at 7:53 AM | #71

    Dear Dr Lee:
    My husband suffered a large Middle Cerebral Artery stroke in February 2012. The cause was an embolic event following an internal carotid dissection, which was believed to be traumatic. He is only 52, and was previously active and healthy without diabetes or hypertension and a total cholesterol of 150 with an HDL of 60. His only risk factor (we have recently discovered) is homozygosity for MTHFRC677T mutation. He has been left with little vision in his left eye, marked weakness in his right upper extremity, moderate right lower extremity weakness, and global aphasia. He has undergone months of in-patient rehabilitation therapy and is still receiving OT,PT and speech therapy as an outpatient. We have tried all types of assistive devices and speech therapy devices (eg Lingraphica) but after modest improvement during the first few months, there has been no further progress. We have run out of options and he is losing hope. Is there a possiblity that stem cell treatment may help him?

    • 3 April, 2013 at 5:45 PM | #72

      Dear Deborah,

      So sorry for the delayed reply; your comment was caught by the spam filter.

      Your husband’s stroke attack from dissection is most unfortunate. A few centres in Kuala Lumpur are collecting cases of acute stroke for stem cell research. Your husband’s year-long duration would disqualify him for this study.

      Studies are now in progress for stem cell transplantation for chronic stroke. Here is one such study for information: http://clinicaltrials.gov/ct2/show/NCT01714167?term=stroke+stem+cell&rank=3
      It is not stated whether dissection cases are excluded from the study.

      Best wishes.

  35. john
    9 January, 2013 at 8:10 AM | #73

    Dear Doctor Lee,
    my six months old baby having duane & hornor syndrome for her right eye. May i know stem cell transplant can help on this ? thanks

    • 10 January, 2013 at 9:50 AM | #74

      Dear John,

      Thank you for your enquiry. There is as yet no study to support the use of stem cells for this rare condition. You will need to be on the lookout for future developments in research in this field.

      Best wishes.

  36. Jessy
    30 December, 2012 at 12:51 PM | #75

    Hi Doctor, my daughter now is 6 months year old, I have stored her cord blood. Now i was thinking that can the cord blood help my baby girl or not. My daughther suffering with heart disease (Complete AVSD) and just done the surgery. She not only the heart problem, she also suffered with the hearing loss and optic disc coloboma (legally blind). According to the Ophthalmology, that is a gab in part of the structures of the eye (no optic nerve), I have search from ASCI – Asian Stem Cell Institute the cord blood can help the optic nerve injuries and the hering loss patien so I would like to know, is that the cord blood can help my daughter, i dont mind to do the testing as long as can help my daughter.

    • 31 December, 2012 at 9:47 AM | #76

      Dear Jessy,

      For information, optic nerve problems require expert advice from the eye experts. Your ophthalmologist is in the best position to provide guidance about this difficult problem. Perhaps what you hope for may prove to be possible in the future.

      Best wishes.

  37. frankie
    12 December, 2012 at 11:01 AM | #77

    Tq for your reply doc,i get your meaning,but i think hypertension only no diabetics maybe better .however, thanks and i have another problem here,,my father in law,sixty years old,told that his brain getting smaller,and he have movement disorder by towing one side of his foot.his ability to speak properly getting worst and cant last stnding still even sometimes unstable till fall backwards.we consult dr soo in kch,neurology in timberland specialist and his diagnosis was minor parkinson disease .may i know,according to all the factor above,izzit my father in law get minor parkinon and if yes ,what can we do,what should we do to prevent his situation getting worst and if any chance of recovery,thanks or your reply

    • 12 December, 2012 at 2:07 PM | #78

      Dear Frankie, Parkinson’s disease is diagnosed by clinical criteria. Once confirmed, treatments will include medications for symptom relief, as well as prevention of disease progression, i.e. neuro-protection.

      Best wishes.

  38. Alaa
    12 December, 2012 at 2:04 AM | #79

    Dear Dr Lee Moon Keen,
    My daughter 10 yrs , has CP. Weight: 22 KG Height: 125 cm
    She is now suffering from the difficulty of speech and inability to form the sentences, as well as lack of consensus and harmony to enable her to walk or control on things naturally.
    She has now a good health and vitality, intelligence and perception of high and the work of all the senses v.well but, has difficulties in reading and writing.
    Is any treatment by stem cell or other, advice or recommend me Pls.

    • 12 December, 2012 at 2:11 PM | #80

      Dear Alaa, stem cell treatment for cerebral palsy is still currently at the investigational stage (i.e. research trials). Since your daughter is at a high functioning level, at present she will derive most benefit from exercise and developmental training.

      Best wishes.

  39. frankie
    12 December, 2012 at 1:33 AM | #81

    Hi , doctor i am a thirty three years old,malaysian kidney failure patient and having three times dialysis per week now.my kidney failure was caused by hypertension and luckily i got no diabetics even thats my family heritage.i had heard about the stem cell transplant or inject can help to generate new cell which can help my kidney.izzit encourgeable for me to do that,our country yet have any confirmation about this,am i right.or doctor have any better idea ,or any place which is reliable and good for it.
    Tq.

  40. Ellie
    10 December, 2012 at 6:53 AM | #82

    Hi
    I have a friend with metastatic colon cancer. Can she go to the Malaysian hospital for stem cell transplant? If so could you please give an stimated price for that.
    Thanks
    Ellie

    • 12 December, 2012 at 2:16 PM | #83

      Dear Ellie, thank you for your enquiry.

      For information, stem cell transplant is currently not performed for metastatic colon cancer.

      Best regards.

  41. 5 December, 2012 at 10:17 AM | #84

    Enquiry from sulaiman:
    sulaiman***@yahoo.com

    HELLO DOCTOR. SAYA SULAIMAN DARI KELANG. ISTERI SAYA MENGIDAP DIABETIS DAN SEKARANG BUAH PINGGANGNYA TELAH ROSAK, MATANYA JUGA TIDAK DAPAT MELIHAT DENGAN JELAS. BOLEH KE RAWATAN DENGAN STEMM CELL MENYEMBUHKAN PENYAKITNYA.

    Our reply:

    Hi Encik Sulaiman

    Keadaan isteri anda agak rumit. Setakat ini, belum terdapat bukti yang rawatan stem cell membawa kesan bagi penyakit buah pinggang atau mata yang berpunca diabetis. Walau bagaimana pun, kini sedang dijalankan beberapa siasatan di institusi di luar negeri, yang membawa hasil seperti buah pinggang yang tumbuh dari stem cell, serta lain jenis rawatan untuk penyakit mata.

    Sehingga penyelidikan begini membawa faedah yang terbukti dengan siasatan RCT (Randomised Controlled Trial), haraplah bersabar dan mengikut rawatan yang diberikan oleh pihak doktor pada masa sekarang.

    Yang benar,

    Dr Lee Moon Keen
    Consultant Neurologist

  42. Yu Yun
    2 December, 2012 at 9:44 PM | #85

    Dear Dr. Lee

    I’m facing a problem where my brother had just got brain damage (left brain internal bleeding) due to stroke 2 weeks ago. He is now currently under treatment in CCU of a government hospital.

    He has gain consciousness after 1 week of treatment and now able to open eyes.
    Despite of opening his eyes, he is able to move his limb but with not much of energy.
    Unfortunately, he is unable to talk and can’t really recognize his family and relatives.

    Kindly advise us whether stem cell therapy can help him recover in short period of time.

  43. Ahmad
    30 November, 2012 at 9:33 AM | #87

    Dear Dr Lee, Currently I am having right Brain stem infact. There is a spot of hyperintense T2/FLAIR signal within the right cerebral peduncle suspious of a lacunar infact. What is the effect of this type stroke? Can this brain stem stroke have better solution with stem cell? If yes, will you do mesynchimal stem cell from own body or from some good resource which has been tested & cultured . Do you will injected it thorigh IV or to the specific area in the brain. I was thinking to move to your hospital since I believe this is the better solution & more advance. Is it cover by insurance ? Please advice & please advice how can I contact you.
    tHANKS.Frm Ahmad

    • 16 December, 2012 at 6:05 PM | #88

      Dear Encik Ahmad,

      Thank you for your enquiry. Please see your email for a private reply.

      Best wishes.

  44. 8 November, 2012 at 11:40 AM | #89

    dear sir

    can stem cell therapy be used for adult with mild spectrum autism
    thank you

    • 8 November, 2012 at 11:10 PM | #90

      Dear Mr Faizul, thank you for your enquiry. For information, stem cell therapy has not been studied in autism spectrum disorder.

  45. ashwani
    31 May, 2012 at 7:10 PM | #91

    Is stem cell treatment advisable for motor neuron disease?

    • 3 June, 2012 at 6:30 PM | #92

      Dear Ashwani, there have been isolated case reports of stem cells for motor neuron disease. For the first in-human trial of embryonic stem cell treatment which is underway in the US, please refer to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154698/pdf/nihms303395.pdf

      • Sakib
        12 June, 2012 at 9:28 PM | #93

        Dear Sir,
        I have gone through the report in the above link and curious to know if there is any stem cell treatment available in Malaysia for the motor neuron patients. I know the full recovery is not possible yet, but hoping for some improvement on life style. Could you please advice ?

      • 17 June, 2012 at 9:09 AM | #94

        Dear Sakib, stem cell treatment is not yet approved for clinical treatment in Malaysia. The regulatory guidelines will of course be revised when there are reports of good treatment outcomes from research studies.

  46. ema
    30 May, 2012 at 3:30 AM | #95

    I got to know stem cell injection can apply for down sdyrome baby? if so need your further explanation.Normally can be done at 8mth age?

    Appreciate your positive reply.

    • 30 May, 2012 at 8:55 AM | #96

      Dear Ema, Thank you for your enquiry. For information, we don’t provide stem cell treatment for this condition. All the best.

  47. robinson
    29 April, 2012 at 9:30 PM | #97

    how about joint problems? what’s your comment about using stem cell in joints?

    • 1 May, 2012 at 7:33 PM | #98

      Dear Robinson, ref. your enquiry, our specialty is in neuroscience. We are not able to comment on the use of stem cells in joint problems.

  48. pamela
    26 March, 2012 at 9:42 PM | #99

    Dear Dr Lee,

    1. What are the side effects of this treatment on humans?

    2. How many humans have thus far volunteered as subjects to this treatment ?

    3. How many success stories? and how many failures ?

    Thank you and all the best,
    Dev

    • 26 March, 2012 at 11:35 PM | #100

      Dear Dev

      Thank you for your interest.

      1. Stem cell treatments are under intensive study worldwide, with concurrent monitoring for side effects. To date there have been no reports of serious side effects. There is a theoretical risk of cancer, as stem cells are also “immortal”.

      2. It is not possible to get accurate figures.

      3. There are promising early results from carefully conducted studies in reputable research centres. Until consistent benefits are documented, no one can claim to have a “success”. However, even unsuccessful research studies provide useful lessons in some way, so they are not viewed as “failures”.

      As such, there is great potential for stem cell treatments but like all medical breakthroughs, the road is long and hard, and much work needs to be done.

      Best.

  49. suriati
    5 April, 2011 at 1:18 AM | #101

    i need to know about this treatment,xspecially for brain damage.

    • 5 April, 2011 at 7:37 AM | #102

      Dear Suriati

      Stem cell treatment is under intensive study as it shows promising results in animal experiments. It is not yet approved for treatment in humans, except in the setting of clinical trials.

  50. May
    8 February, 2011 at 7:06 PM | #103

    Bravo, Dr. Lee. You made me so proud to be a Malaysian.

  51. James
    9 November, 2010 at 5:05 PM | #104

    Dr. Lee you have done your fellow Malaysian proud. I believe this is the way forward to prove the science behind Stem Cells therapy. Keep it up!!

  52. 16 August, 2010 at 8:20 PM | #105

    Very Interesting!
    Thank You!

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